Kava Extract / 30% Kavalactones HPLC from GMP manufacturer

Specifications

Kava extract

Latin name: Piper methyticum L

Part of Plant Used: Root

Herbal Origin: Growth in islands of the South Pacific like Fiji, Tonga, Samoa, and Vanuatu. 

Active Ingredients: Kavalactones

Specifications: 4:1-200:1, 30%-70% Kavalactones
Test Method: HPLC
Appearance: Yellow fine powder  

CAS No.: 9000-38-8 

Molecular Formula: C15H14O5

Molecular Weight: 274.269

Solubility: not solute in water, solute in organic solvents

Introduction:

    Kava is an herbaceous plant used frequently in herbal medicine to treat anxiety and insomnia. It is native to the South Pacific islands, and its root has been used ceremonially, recreationally, and medicinally for centuries. Consuming kava extract produces a feeling of mild euphoria, and is known for its relaxation and anti-convulsant effects. In Western culture, it is commonly prescribed by herbalists and alternative medicine practitioners for all types of anxiety disorders.

    Aside from the strong anecdotal evidence available for the use of kava-kava extract, there is also a growing body of scientific studies which back its efficacy for the treatment of anxiety. A recent study published in the Cochrane Database of Systematic Reviews states that kava extract is an effective symptomatic treatment for anxiety, and is relatively safe for short term treatment.

    Another study published in a 2002 edition of the scientific journal, Life Sciences, found that kava is very effective in treating anxiety without causing a loss of mental acuity. It is shown to have minimal negative side effects and may even cause positive effects, such as an increase of cognitive processing and reaction time. According to the study, kava-kava is non-addictive and well tolerated by most patients.

Active Ingredients:

    The active ingredients that make kava extract so effective against anxiety are kavalactones which are found in the plant’s roots. They have the ability to improve mood by increasing dopamine levels. It is unclear exactly how this process works. However, when an individual consumes kava-kava in any form, the kavalactones affect the neurotransmitters, or chemicals that carry messages between cells, in the blood.

Benefits

• Relieves mild to moderate depression
• Relieves insomnia and promotes sleep
• Mental Support
• Analgesic and spasmolytic Effects

• Neuroprotective
• Antimitotic
• Anticancer Effects

Mechanism

Effects of kavalactones include mild sedation, a slight numbing of the gums and mouth, and vivid dreams. Kava has been reported to improve cognitive performance and promote a cheerful mood. Muscle relaxant, anaesthetic, anticonvulsive and anxiolytic effects are thought to result from direct interactions of kavalactones with voltage-gated ion channels. Research currently suggests that kavalactones potentiate GABAA activity but do not alter levels of dopamine and serotonin in the CNS. Heavy, long-term kava use does not cause any reduction of ability in saccade and cognitive tests but is associated with elevated liver enzymes.

Desmethoxyyangonin, one of the six major kavalactones, is a reversible MAO-B inhibitor  and is able to increase dopamine levels in the nucleus accumbens. This finding might correspond to the slightly euphoric action of kava.

Safety

Kava Extract is safe.
The kava extracts with stems and leaves are of liver damage.
Chronic and heavy use of kava for a period of three months or more has occasionally been reported to cause a scaly, yellow skin rash and an eye irritation that disappears after discontinuation of the herb.

Dosage

• The typical dose is 200-500mg per day (usually in 2-3 doses throughout the day).
• Consult physicians for different condition specifics.

Functions:
To remove tension and stress
To cure worry and losing sleep
To ease muscular tone.

Applications:

1. Applied in beverage,kava drinks are consumed in some parts of the world in much the same way as alcohol

2. Applied in pharmaceutical field, in capsule, tablet, and liquid extract forms

Package: 1kg/plastic bag outside Au-bag

                   25kg/double plastic bag outside drum(or carton)

Storage: Store in cool & dry place, keep away from strong light and heat.

Certificate of Analysis

Our advantages:

1. Our factory was conducted Onsite assessment by TUV Rheinland from Germany. And we have passed the ISO9001, Chinese Health Food GMP.

2. We inspect the manufacture process strictly and the quality can be controlled;

3. We supply high quality products, reasonable price, prompt delivery

4. Or best quality extract with natural and pure. No additives, organically grown